GEM 21S® Promotes rapid healing and new bone formation for oral surgery1,2

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GEM 21S® is a synthetic bone graft composed of purified, sterile recombinant human platelet-derived growth factor (rhPDGF) and a β-TCP.

PDGF is naturally found in the body (present in the platelets in your blood) and is often referred to as nature’s wound healing protein. GEM 21S® increases the amount of PDGF at the grafted site to aid in faster, more bone and better healing.1

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How do you 4C predictability?

Consistency

The first and only off-the-shelf source of purified rhPDGF approved for bone and soft tissue regeneration.1

Cellular Attraction

GEM 21S® signals and recruits the specific cells that the body needs to regenerate bone and the surrounding tissues (chemotaxis).2

Cellular Proliferation

Once the cells migrate to the site, cell proliferation occurs (mitogenesis). This cellular activity stimulates angiogenesis, resulting in more rapid healing and new bone formation.1

Clinical Outcomes

GEM 21S® is one of the most researched growth factors in dentistry. It has been proven to be safe and effective in regenerating bone and soft tissue in more than 500 publications and 60+ clinical studies.3

500+Publications

60+Clinical Studies

1,650Defects Analyzed

~11 monthsMean Follow-up

5 millionPatients Treated

“In dealing with periodontal defects, one of my favorite biomaterials to use is GEM 21S® which is a highly purified recombinant human platelet-derived growth factor (rhPDGF-BB).”

Dr. John Kim, DMD, MS, PA

We harness the body’s healing power

Lynch Biologics, LLC is a Geistlich North America company offering a variety of oral/dental regenerative products for use in bone and gingival tissue defects. We believe the key is the introduction of signaling molecules, like a protein we use called Platelet-Derived Growth Factor, or rhPDGF-BB. This protein is naturally found in the body and its presence supports the growth of STEM cells, which together with tissue scaffolds provide the building blocks for the development of new, healthy blood vessels and tissues. The goal is to harness this natural, normal process, enabling your body to heal itself, faster.

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UPCOMING EVENT

Maximizing Success: Allograft Applications in Everyday Practice

May 28, 2025
8:00 – 9:00 PM EST

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  1. Nevins M. et al.: J Periodontol. 2003 Sep; 74(9):1282-92.
  2. Based on in-vitro and in-vivo data; see device description on GEM 21S® package insert for complete information
  3. Data on file, Lynch Biologics, LLC

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